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Landmark trials include STEP (semaglutide for weight management, NEJM 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)
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It also promotes healthy systemic metabolic outcomes within the gut lining
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Within the cholesterol metabolism pathway, we observed a significant upregulation of Abcg5 and Abcg8 after tirzepatide treatment
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